CHOOSE fruit juice as a drink while swallowing the drugs seem needs to be avoided. A recent research indicates, fruit juice can affect the body's ability to absorb the drugs, making treatment less effective healing.
The pharmacists in Canada in research published on Wednesday (20 / 8), stating that grapefruit juice (orange red), orange and apple juice shown to interfere with the body's ability to absorb certain medications and reducing the effectiveness of therapy. Based on the results of the study, fruit juice can reduce the effectiveness of the drugs used for heart disease, cancer, organ transplants and "potentially eliminating the effect of usefulness."
David Bailey, professor of clinical pharmacology from the University of Western Ontario, who led the research, was the first to identify the potential of grapefruit juice increases the absorption of certain drugs, as well as examine the possibilities of turning normal doses into overdose. Latest findings, which is an advanced research Bailey, presented at the annual meeting of the American Chemical Society in Philadelphia 236.
"When we use the drugs, you should drink it with appropriate doses. Dose is too low will not give the effect you want, chances are too high will lead to excessive or basic produce toxic effects,"
"Not long ago, we found that the substance contained in grapefruit and other fruit juice may decrease the oral absorption of certain drugs during the transportation process absorption in the digestive tissue. The problem is the loss of efficacy of treatment is very important for the healing of serious illnesses, "said Bailey
In his research, Bailey volunteers to take fexofenadine, an antihistamine to overcome the kind of allergy. The volunteers swallowed the drug with a choice of drinking a glass of grapefruit juice and plain water and water mixed with naringin (substance that gives the sour taste of fruits). The results showed that volunteers who drank the grapefruit juice absorbed only half of it fexofenadine levels than those who drank plain water.
According to researchers, grapefruit juice contains naringin, the main ingredient, which gives a sense of wry and distinctive aroma. Naringin is believed to block the "transporter" of drugs called OATP1A2 which transports the active ingredients of drugs from the small intestine into the blood vessels.
"Blocking this transporter reduces drug absorption and neutralizes the potential benefits. On the other hand, drugs whose levels are increased by the presence of grapefruit juice appear to block an enzyme important in the metabolism of drugs called CYP3A4, that normally serves to break the drug, "researchers said.
In addition to grapefruit, the researchers found that orange juice and apple juice which was more drunk than grapefruit juice also showed the same effect. Both types of juice, the researchers say, does contain naringin.
So far, among the drugs that are affected by consumption of grapefruit, orange and apple juices are: etoposide, an anticancer drug type; types of beta blockers (atenolol, celiprolol, talinolol) used to treat high blood pressure and prevent heart attacks and some types of antibiotics (ciprofloxacin, levofloxacin, itraconazole). Also experienced a decrease cyclosporine drug interactions - drugs used to prevent rejection in organ transplantation. List An estimated these drugs will continue to grow long as the research continued.
Bailey said patients should consult with your doctor about the possible influence of drug consumption in juice beverage. He also asked the patient should be disciplined use of water when ingesting the drug.
David Bailey, professor of clinical pharmacology from the University of Western Ontario, who led the research, was the first to identify the potential of grapefruit juice increases the absorption of certain drugs, as well as examine the possibilities of turning normal doses into overdose. Latest findings, which is an advanced research Bailey, presented at the annual meeting of the American Chemical Society in Philadelphia 236.
"When we use the drugs, you should drink it with appropriate doses. Dose is too low will not give the effect you want, chances are too high will lead to excessive or basic produce toxic effects,"
"Not long ago, we found that the substance contained in grapefruit and other fruit juice may decrease the oral absorption of certain drugs during the transportation process absorption in the digestive tissue. The problem is the loss of efficacy of treatment is very important for the healing of serious illnesses, "said Bailey
In his research, Bailey volunteers to take fexofenadine, an antihistamine to overcome the kind of allergy. The volunteers swallowed the drug with a choice of drinking a glass of grapefruit juice and plain water and water mixed with naringin (substance that gives the sour taste of fruits). The results showed that volunteers who drank the grapefruit juice absorbed only half of it fexofenadine levels than those who drank plain water.
According to researchers, grapefruit juice contains naringin, the main ingredient, which gives a sense of wry and distinctive aroma. Naringin is believed to block the "transporter" of drugs called OATP1A2 which transports the active ingredients of drugs from the small intestine into the blood vessels.
"Blocking this transporter reduces drug absorption and neutralizes the potential benefits. On the other hand, drugs whose levels are increased by the presence of grapefruit juice appear to block an enzyme important in the metabolism of drugs called CYP3A4, that normally serves to break the drug, "researchers said.
In addition to grapefruit, the researchers found that orange juice and apple juice which was more drunk than grapefruit juice also showed the same effect. Both types of juice, the researchers say, does contain naringin.
So far, among the drugs that are affected by consumption of grapefruit, orange and apple juices are: etoposide, an anticancer drug type; types of beta blockers (atenolol, celiprolol, talinolol) used to treat high blood pressure and prevent heart attacks and some types of antibiotics (ciprofloxacin, levofloxacin, itraconazole). Also experienced a decrease cyclosporine drug interactions - drugs used to prevent rejection in organ transplantation. List An estimated these drugs will continue to grow long as the research continued.
Bailey said patients should consult with your doctor about the possible influence of drug consumption in juice beverage. He also asked the patient should be disciplined use of water when ingesting the drug.
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